HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	32707033, 19996089, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 576
+	Hs
		437937 HS90B_HUMAN (1-724): 0: 1086: 100.00		GRK5_HUMAN (1-563): 1.85e-175: 510: 71.76
+	Hs
		437932 HS90B_HUMAN (1-724): 0: 1086: 100.00		GRK4_HUMAN (1-575): 1.17e-168: 492: 65.34
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (9-508): 8.49e-153: 456: 24.32
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (11-507): 2.06e-147: 444: 24.09
+	Hs
		437909 HS90B_HUMAN (1-724): 0: 1086: 100.00		ARBK1_HUMAN (2-541): 2.79e-147: 442: 36.59
+	Hs
		438392 HS90B_HUMAN (1-724): 0: 1086: 100.00		GRK7_HUMAN (3-541): 2.39e-146: 435: 44.14
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (75-497): 2.96e-144: 427: 30.59
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (11-510): 1.35e-142: 429: 24.61
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (75-496): 8.41e-145: 428: 30.97
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (75-497): 6.77e-145: 428: 30.59
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (75-497): 3.54e-143: 424: 30.59
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (75-496): 7.73e-143: 423: 30.82
+	Hs
		437870 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCA_HUMAN (144-500): 5.83e-144: 421: 28.85
+	Hs
		437900 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCB_HUMAN (144-500): 4.26e-143: 419: 29.69
+	Hs
		437898 HS90B_HUMAN (1-724): 0: 1086: 100.00		KAPCG_HUMAN (144-500): 1.69e-142: 417: 26.89
+	Hs
		70435 HS90A_HUMAN (1-724): 0: 1072: 85.25		B2RB89_HUMAN (144-500): 4.26e-143: 419: 29.69
+	Hs
		437869 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCA_HUMAN (176-496): 1.87e-58: 208: 38.08
+	Hs
		408529 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCB_HUMAN (191-498): 2.23e-57: 205: 38.07
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (186-485): 2.72e-57: 201: 39.09
+	Hs
		408527 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCB_HUMAN (191-498): 2.23e-57: 205: 38.07