HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042826 - histone deacetylase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 1084
+	Hs
		431699 HS90A_HUMAN (1-724): 0: 1072: 85.25		HDAC4_HUMAN (1-1072): 0: 974: 100.00
+	Hs
		538171 ENPL_HUMAN (3-693): 0: 917: 46.44		HDAC4_HUMAN (1-1072): 0: 974: 100.00
+	Hs
		438630 HS90B_HUMAN (1-724): 0: 1086: 100.00		HDAC5_HUMAN (1-1084): 0: 785: 55.67
+	Hs
		432372 HS90A_HUMAN (1-724): 0: 1072: 85.25		HDAC5_HUMAN (1-1084): 0: 785: 55.67
+	Mm
		435921 ENPL_MOUSE (3-724): 0: 920: 45.29		Q3UJF1_MOUSE (2-1084): 0: 783: 55.84
+	Hs
		538445 ENPL_HUMAN (3-693): 0: 917: 46.44		HDAC5_HUMAN (1-1084): 0: 785: 55.67
+	Mm
		435936 ENPL_MOUSE (3-724): 0: 920: 45.29		HDAC5_MOUSE (1-1084): 0: 779: 55.24
+	Hs
		438145 HS90B_HUMAN (1-724): 0: 1086: 100.00		HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68
+	Hs
		438407 HS90B_HUMAN (1-724): 0: 1086: 100.00		HDAC2_HUMAN (647-1082): 7.5e-161: 486: 20.97
+	Hs
		432123 HS90A_HUMAN (1-724): 0: 1072: 85.25		HDAC2_HUMAN (647-1082): 7.5e-161: 486: 20.97
+	Mm
		513711 HS90B_MOUSE (1-724): 0: 1089: 99.59		HDAC6_MOUSE (576-1033): 2.07e-111: 375: 33.12
+	Hs
		438583 HS90B_HUMAN (1-724): 0: 1086: 100.00		HDAC6_HUMAN (574-1040): 2.26e-108: 368: 32.62
+	Hs
		432325 HS90A_HUMAN (1-724): 0: 1072: 85.25		HDAC6_HUMAN (574-1040): 2.26e-108: 368: 32.62
+	Hs
		538432 ENPL_HUMAN (3-693): 0: 917: 46.44		HDAC6_HUMAN (574-1040): 2.26e-108: 368: 32.62
+	Hs
		432230 HS90A_HUMAN (1-724): 0: 1072: 85.25		HDAC8_HUMAN (669-962): 5.23e-24: 107: 27.22
+	Zm
		35492 A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66		A0A1D6N7T5_MAIZE (810-1025): 6.92e-36: 137: 35.68
+	Hs
		1162533 Q6PK50_HUMAN (1-350): 0: 618: 99.71		HDAC6_HUMAN (574-1040): 2.26e-108: 368: 32.62