HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CDK3 (Q00526)
Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
Gene: CDK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	26186194, 28514442, 33961781, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 305
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (1-290): 1.16e-137: 392: 65.98
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK5_HUMAN (1-292): 8.97e-133: 380: 60.75
+	Hs
		438004 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		431662 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (1-292): 1.87e-148: 420: 76.71
+	Sc
		339312 HSP82_YEAST (12-724): 0: 927: 61.26		CDK1_YEAST (3-288): 1.32e-131: 377: 63.92
+	Ca
		793050 HSP90_CANAL (8-724): 0: 929: 60.42		CDK1_CANAL (1-286): 3e-130: 374: 66.78
+	Sc
		365744 HSP82_YEAST (12-724): 0: 927: 61.26		PHO85_YEAST (3-290): 9.48e-130: 373: 54.21
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 929: 62.48		CDK1_SCHPO (1-288): 1.98e-129: 371: 63.05
+	Sc
		339406 HSC82_YEAST (13-724): 0: 922: 60.22		CDK1_YEAST (3-288): 1.32e-131: 377: 63.92
+	Sc
		543138 HSC82_YEAST (13-724): 0: 922: 60.22		PHO85_YEAST (3-290): 9.48e-130: 373: 54.21
+	Hs
		841224 H90B3_HUMAN (1-724): 0: 815: 75.83		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64
+	Hs
		960099 H90B4_HUMAN (25-596): 0: 639: 71.85		CDK3_HUMAN (1-305): 1.8e-151: 427: 100.00
+	Hs
		841223 H90B4_HUMAN (25-596): 0: 639: 71.85		CDK7_HUMAN (3-296): 2.86e-124: 360: 45.64