HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TYRO3 (Q06418)
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
Gene: TYRO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	35384245, 22939624
Identification Methods	affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 890
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (72-826): 3.64e-180: 547: 19.92
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (119-820): 7.18e-173: 528: 20.61
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (116-832): 1.86e-165: 509: 21.01
+	Hs
		437946 HS90B_HUMAN (1-724): 0: 1086: 100.00		TIE1_HUMAN (43-796): 2.59e-153: 481: 24.13
+	Hs
		437892 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA1_HUMAN (203-829): 5.58e-141: 445: 26.19
+	Hs
		437816 HS90B_HUMAN (1-724): 0: 1086: 100.00		MET_HUMAN (495-790): 3.89e-65: 240: 41.67
+	Hs
		435497 HS90B_HUMAN (1-724): 0: 1086: 100.00		IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53
+	Hs
		431438 HS90A_HUMAN (1-724): 0: 1072: 85.25		IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53
+	Hs
		337314 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76
+	Hs
		437855 HS90B_HUMAN (1-724): 0: 1086: 100.00		INSRR_HUMAN (513-780): 3.2e-53: 204: 39.56
+	Hs
		69196 HS90B_HUMAN (1-724): 0: 1086: 100.00		A9UEZ6_HUMAN (519-878): 3.4e-53: 204: 36.76
+	Hs
		438096 HS90B_HUMAN (1-724): 0: 1086: 100.00		FAK1_HUMAN (510-832): 6.04e-53: 202: 35.14
+	Hs
		431435 HS90A_HUMAN (1-724): 0: 1072: 85.25		RET_HUMAN (514-790): 1.89e-55: 210: 39.93
+	Hs
		337312 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL1_HUMAN (519-878): 6.21e-54: 205: 36.76
+	Hs
		169160 HS90B_HUMAN (1-724): 0: 1086: 100.00		MUSK_HUMAN (42-257): 7.52e-27: 119: 16.59
+	Hs
		169159 HS90A_HUMAN (1-724): 0: 1072: 85.25		MUSK_HUMAN (42-257): 7.52e-27: 119: 16.59
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (6-230): 2.63e-19: 95.6: 18.22
+	Hs
		437897 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR3_HUMAN (7-315): 1.59e-17: 89.8: 14.60
+	Hs
		437923 HS90B_HUMAN (1-724): 0: 1086: 100.00		UFO_HUMAN (6-344): 1.91e-14: 79.8: 14.56
+	Hs
		438114 HS90B_HUMAN (1-724): 0: 1086: 100.00		MERTK_HUMAN (6-315): 1.52e-12: 73.6: 15.71