HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	21145461, 22939624
Identification Methods	affinity chromatography technology, tandem affinity purification, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 759
+	Hs
		431832 HS90A_HUMAN (1-724): 0: 1072: 85.25		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		438154 HS90B_HUMAN (1-724): 0: 1086: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		431833 HS90A_HUMAN (1-724): 0: 1072: 85.25		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		438152 HS90B_HUMAN (1-724): 0: 1086: 100.00		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		431831 HS90A_HUMAN (1-724): 0: 1072: 85.25		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		538227 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		538228 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		438150 HS90B_HUMAN (1-724): 0: 1086: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		431829 HS90A_HUMAN (1-724): 0: 1072: 85.25		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		438151 HS90B_HUMAN (1-724): 0: 1086: 100.00		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		431830 HS90A_HUMAN (1-724): 0: 1072: 85.25		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		538226 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		438412 HS90B_HUMAN (1-724): 0: 1086: 100.00		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Hs
		538224 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		432131 HS90A_HUMAN (1-724): 0: 1072: 85.25		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Hs
		1041725 H90B3_HUMAN (1-724): 0: 815: 75.83		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		538225 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL2_HUMAN (51-759): 0: 710: 27.00
+	Hs
		538342 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL5_HUMAN (59-759): 0: 589: 24.94
+	Sc
		367047 HSP82_YEAST (12-724): 0: 927: 61.26		CDC53_YEAST (52-759): 0: 561: 21.90
+	Sc
		544559 HSC82_YEAST (13-724): 0: 922: 60.22		CDC53_YEAST (52-759): 0: 561: 21.90