HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TOM34 (Q15785)
Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit)
Gene: TOMM34

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0016020 - membrane GO:0031072 - heat shock protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 309
+	Mm
		513680 HS90B_MOUSE (1-724): 0: 1089: 99.59		PPP5_MOUSE (9-135): 4.34e-26: 109: 25.20
+	Hs
		438021 HS90B_HUMAN (1-724): 0: 1086: 100.00		PPP5_HUMAN (5-179): 1.5e-25: 107: 20.99
+	Hs
		438533 HS90B_HUMAN (1-724): 0: 1086: 100.00		RPAP3_HUMAN (2-139): 1.49e-22: 99.8: 25.36
+	Hs
		438089 HS90B_HUMAN (1-724): 0: 1086: 100.00		FKBP4_HUMAN (4-180): 2.23e-21: 95.6: 22.83
+	Hs
		111935 K9JA46_HUMAN (1-724): 0: 1072: 85.25		PPP5_HUMAN (5-179): 1.5e-25: 107: 20.99
+	Hs
		431681 HS90A_HUMAN (1-724): 0: 1072: 85.25		PPP5_HUMAN (5-179): 1.5e-25: 107: 20.99
+	Hs
		431774 HS90A_HUMAN (1-724): 0: 1072: 85.25		SPAG1_HUMAN (2-309): 1.22e-23: 103: 17.68
+	Hs
		111936 K9JA46_HUMAN (1-724): 0: 1072: 85.25		FKBP4_HUMAN (4-180): 2.23e-21: 95.6: 22.83
+	Hs
		431755 HS90A_HUMAN (1-724): 0: 1072: 85.25		FKBP4_HUMAN (4-180): 2.23e-21: 95.6: 22.83
+	Hs
		438464 HS90B_HUMAN (1-724): 0: 1086: 100.00		DNJC7_HUMAN (4-171): 5.63e-16: 79.8: 23.21
+	Hs
		438136 HS90B_HUMAN (1-724): 0: 1086: 100.00		FKBP5_HUMAN (167-298): 1.23e-12: 69.7: 29.93
+	Hs
		174561 HS90B_HUMAN (1-724): 0: 1086: 100.00		OGT1_HUMAN (189-302): 3.62e-12: 69: 9.65
+	Hs
		437930 HS90B_HUMAN (1-724): 0: 1086: 100.00		STIP1_HUMAN (3-195): 1.3e-11: 67.1: 11.85
+	Hs
		297025 HS90B_HUMAN (1-724): 0: 1086: 100.00		TOM70_HUMAN (89-307): 1.1e-09: 60.9: 11.95
+	Hs
		438524 HS90B_HUMAN (1-724): 0: 1086: 100.00		UN45A_HUMAN (8-206): 2.62e-09: 60.1: 26.24
+	Hs
		111937 K9JA46_HUMAN (1-724): 0: 1072: 85.25		FKBP5_HUMAN (167-298): 1.23e-12: 69.7: 29.93
+	Hs
		174556 HS90A_HUMAN (1-724): 0: 1072: 85.25		OGT1_HUMAN (189-302): 3.62e-12: 69: 9.65
+	Hs
		111934 K9JA46_HUMAN (1-724): 0: 1072: 85.25		STIP1_HUMAN (3-195): 1.3e-11: 67.1: 11.85
+	Hs
		431574 HS90A_HUMAN (1-724): 0: 1072: 85.25		STIP1_HUMAN (3-195): 1.3e-11: 67.1: 11.85
+	Hs
		297024 HS90A_HUMAN (1-724): 0: 1072: 85.25		TOM70_HUMAN (89-307): 1.1e-09: 60.9: 11.95