HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0042803 - protein homodimerization activity GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 822
+	Hs
		438205 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		437895 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		431534 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		437897 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384122 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		384111 HS90A_HUMAN (1-724): 0: 1072: 85.25		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		431472 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (149-822): 1.29e-142: 447: 23.00
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		431435 HS90A_HUMAN (1-724): 0: 1072: 85.25		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		438220 HS90B_HUMAN (1-724): 0: 1086: 100.00		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		435497 HS90B_HUMAN (1-724): 0: 1086: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		438084 HS90B_HUMAN (1-724): 0: 1086: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		437855 HS90B_HUMAN (1-724): 0: 1086: 100.00		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		431438 HS90A_HUMAN (1-724): 0: 1072: 85.25		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		438619 HS90B_HUMAN (1-724): 0: 1086: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		431488 HS90A_HUMAN (1-724): 0: 1072: 85.25		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		169160 HS90B_HUMAN (1-724): 0: 1086: 100.00		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92
+	Hs
		169159 HS90A_HUMAN (1-724): 0: 1072: 85.25		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92