HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: PDK4 (Q16654)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)
Gene: PDK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HATPase_c~HSP90
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 411
+	Hs
		431902 HS90A_HUMAN (1-724): 0: 1072: 85.25		PDK4_HUMAN (1-411): 0: 644: 100.00
+	Hs
		438184 HS90B_HUMAN (1-724): 0: 1086: 100.00		PDK3_HUMAN (1-407): 0: 602: 61.37
+	Hs
		438183 HS90B_HUMAN (1-724): 0: 1086: 100.00		PDK2_HUMAN (1-406): 0: 600: 63.88
+	Hs
		431866 HS90A_HUMAN (1-724): 0: 1072: 85.25		PDK3_HUMAN (1-407): 0: 602: 61.37
+	Hs
		431865 HS90A_HUMAN (1-724): 0: 1072: 85.25		PDK2_HUMAN (1-406): 0: 600: 63.88
+	Hs
		157283 HS90B_HUMAN (1-724): 0: 1086: 100.00		BCKD_HUMAN (52-369): 2.27e-125: 370: 29.43
+	Hs
		157282 HS90A_HUMAN (1-724): 0: 1072: 85.25		BCKD_HUMAN (52-369): 2.27e-125: 370: 29.43
+	Sc
		543884 HSC82_YEAST (13-724): 0: 922: 60.22		PDK1_YEAST (14-372): 3.63e-111: 333: 23.73
+	Sc
		366625 HSP82_YEAST (12-724): 0: 927: 61.26		PDK2_YEAST (24-305): 1.58e-80: 257: 25.42