HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CDKL4 (Q5MAI5)
Cyclin-dependent kinase-like 4 (EC 2.7.11.22)
Gene: CDKL4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26186194
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 379
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (1-292): 3.58e-140: 402: 37.76
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (1-297): 3.87e-138: 397: 39.47
+	Mm
		513710 HS90B_MOUSE (1-724): 0: 1089: 99.59		MK07_MOUSE (2-365): 1.9e-130: 394: 25.33
+	Rn
		92848 HS90B_RAT (1-724): 0: 1089: 99.59		E9PTH2_RAT (2-365): 1.88e-130: 394: 25.33
+	Hs
		438129 HS90B_HUMAN (1-724): 0: 1086: 100.00		MK07_HUMAN (2-365): 5.34e-131: 396: 24.80
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (1-292): 3.58e-140: 402: 37.76
+	Hs
		431937 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDKL4_HUMAN (1-379): 2.28e-137: 398: 100.00
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (1-297): 3.87e-138: 397: 39.47
+	Hs
		431807 HS90A_HUMAN (1-724): 0: 1072: 85.25		MK07_HUMAN (2-365): 5.34e-131: 396: 24.80
+	Hs
		432124 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDKL2_HUMAN (1-334): 1e-134: 395: 49.57
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK5_HUMAN (1-292): 1.51e-130: 377: 37.76
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (1-291): 4.58e-132: 381: 37.42
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK5_HUMAN (1-292): 1.51e-130: 377: 37.76
+	Mm
		513676 HS90B_MOUSE (1-724): 0: 1089: 99.59		CDKL5_MOUSE (1-288): 5.7e-86: 281: 46.74
+	Hs
		438004 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		438342 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK20_HUMAN (1-286): 1.24e-59: 198: 38.41
+	Hs
		431662 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		432045 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK20_HUMAN (1-286): 1.24e-59: 198: 38.41
+	Sc
		365744 HSP82_YEAST (12-724): 0: 927: 61.26		PHO85_YEAST (3-289): 2.76e-63: 206: 37.00
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 929: 62.48		CDK1_SCHPO (1-290): 6.66e-60: 197: 33.99