HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 861
+	Hs
		431943 HS90A_HUMAN (1-724): 0: 1072: 85.25		HECD3_HUMAN (1-861): 0: 1137: 100.00
+	Hs
		125101 HS90B_HUMAN (1-724): 0: 1086: 100.00		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		438516 HS90B_HUMAN (1-724): 0: 1086: 100.00		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		125097 HS90A_HUMAN (1-724): 0: 1072: 85.25		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		432252 HS90A_HUMAN (1-724): 0: 1072: 85.25		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		438309 HS90B_HUMAN (1-724): 0: 1086: 100.00		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		432005 HS90A_HUMAN (1-724): 0: 1072: 85.25		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		538146 ENPL_HUMAN (3-693): 0: 917: 46.44		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Sc
		366333 HSP82_YEAST (12-724): 0: 927: 61.26		RSP5_YEAST (371-855): 1.15e-164: 501: 18.53
+	Sc
		543785 HSC82_YEAST (13-724): 0: 922: 60.22		RSP5_YEAST (371-855): 1.15e-164: 501: 18.53
+	Hs
		538295 ENPL_HUMAN (3-693): 0: 917: 46.44		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Sc
		366793 HSP82_YEAST (12-724): 0: 927: 61.26		TOM1_YEAST (436-849): 1.84e-118: 398: 23.61
+	Sc
		544310 HSC82_YEAST (13-724): 0: 922: 60.22		TOM1_YEAST (436-849): 1.84e-118: 398: 23.61
+	Hs
		438178 HS90B_HUMAN (1-724): 0: 1086: 100.00		CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63
+	Hs
		319705 ENPL_HUMAN (3-693): 0: 917: 46.44		HERC2_HUMAN (237-372): 5.72e-44: 175: 35.77
+	Zm
		17433 A0A1D6GWE1_MAIZE (13-690): 0: 564: 47.81		A0A1D6MU59_MAIZE (425-853): 5.37e-142: 467: 21.45
+	Hs
		538246 ENPL_HUMAN (3-693): 0: 917: 46.44		UBE3C_HUMAN (495-845): 2.66e-20: 99: 27.64
+	Hs
		538235 ENPL_HUMAN (3-693): 0: 917: 46.44		CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63