HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: M3K21 (Q5TCX8)
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)
Gene: MAP3K21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1036
+	Hs
		431947 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K21_HUMAN (1-1036): 0: 701: 100.00
+	Hs
		438088 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K10_HUMAN (32-1021): 0: 570: 44.87
+	Hs
		438073 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K9_HUMAN (38-1036): 0: 561: 47.56
+	Hs
		431754 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K10_HUMAN (32-1021): 0: 570: 44.87
+	Hs
		431735 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K9_HUMAN (38-1036): 0: 561: 47.56
+	Hs
		438211 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K11_HUMAN (32-888): 7.63e-141: 445: 44.47
+	Hs
		431899 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K11_HUMAN (32-888): 7.63e-141: 445: 44.47
+	Hs
		438103 HS90B_HUMAN (1-724): 0: 1086: 100.00		ACK1_HUMAN (66-934): 2.9e-126: 412: 18.03
+	Hs
		438348 HS90B_HUMAN (1-724): 0: 1086: 100.00		MINK1_HUMAN (104-1027): 1.61e-122: 408: 15.40
+	Hs
		337314 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL1_HUMAN (68-887): 6.57e-122: 402: 18.07
+	Hs
		438113 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K12_HUMAN (103-895): 1.14e-123: 400: 24.51
+	Hs
		431776 HS90A_HUMAN (1-724): 0: 1072: 85.25		ACK1_HUMAN (66-934): 2.9e-126: 412: 18.03
+	Hs
		432054 HS90A_HUMAN (1-724): 0: 1072: 85.25		MINK1_HUMAN (104-1027): 1.61e-122: 408: 15.40
+	Hs
		337312 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL1_HUMAN (68-887): 6.57e-122: 402: 18.07
+	Hs
		431787 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K12_HUMAN (103-895): 1.14e-123: 400: 24.51
+	Hs
		437967 HS90B_HUMAN (1-724): 0: 1086: 100.00		FRK_HUMAN (98-399): 2.48e-102: 332: 30.77
+	Hs
		431627 HS90A_HUMAN (1-724): 0: 1072: 85.25		FRK_HUMAN (98-399): 2.48e-102: 332: 30.77
+	Dm
		365472 HSP83_DROME (10-724): 0: 1057: 78.46		SRC42_DROME (90-415): 4.54e-102: 332: 27.03
+	Zm
		8229 A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66		A0A1D6ELX5_MAIZE (111-409): 6.59e-104: 344: 34.22
+	At
		287794 HS905_ARATH (1-724): 0: 885: 43.56		O82754_ARATH (115-401): 1.01e-37: 154: 34.48