HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	32707033, 35384245, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 422
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (5-417): 7.24e-127: 391: 19.38
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		437897 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR3_HUMAN (10-409): 1.6e-125: 383: 27.01
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (46-411): 2.25e-121: 377: 21.95
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		169160 HS90B_HUMAN (1-724): 0: 1086: 100.00		MUSK_HUMAN (24-393): 4.95e-119: 368: 22.28
+	Hs
		437895 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		169159 HS90A_HUMAN (1-724): 0: 1072: 85.25		MUSK_HUMAN (24-393): 4.95e-119: 368: 22.28
+	Hs
		437847 HS90B_HUMAN (1-724): 0: 1086: 100.00		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		411949 HS90B_HUMAN (1-724): 0: 1086: 100.00		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		437967 HS90B_HUMAN (1-724): 0: 1086: 100.00		FRK_HUMAN (83-386): 1.13e-109: 333: 28.25
+	Hs
		433218 HS90B_HUMAN (1-724): 0: 1086: 100.00		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Hs
		411945 HS90A_HUMAN (1-724): 0: 1072: 85.25		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		431433 HS90A_HUMAN (1-724): 0: 1072: 85.25		YES_HUMAN (88-390): 1.93e-108: 331: 28.76
+	Hs
		337314 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		69196 HS90B_HUMAN (1-724): 0: 1086: 100.00		A9UEZ6_HUMAN (143-387): 1.01e-40: 156: 35.34
+	Hs
		437966 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL2_HUMAN (143-381): 3.74e-40: 155: 36.63
+	Hs
		337312 HS90A_HUMAN (1-724): 0: 1072: 85.25		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		437946 HS90B_HUMAN (1-724): 0: 1086: 100.00		TIE1_HUMAN (120-380): 8.51e-36: 142: 32.96
+	Hs
		437960 HS90B_HUMAN (1-724): 0: 1086: 100.00		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89