HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 601
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (219-542): 1.22e-134: 396: 27.80
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (219-542): 1.22e-134: 396: 27.80
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70
+	Hs
		438162 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK13_HUMAN (3-598): 8.85e-117: 381: 19.87
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (56-530): 5.62e-123: 380: 18.30
+	Hs
		438553 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYRK4_HUMAN (119-595): 5.24e-124: 377: 44.24
+	Hs
		431752 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (38-510): 5.5e-118: 367: 17.08
+	Hs
		438155 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		431762 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCT_HUMAN (56-530): 5.62e-123: 380: 18.30
+	Hs
		438648 HS90B_HUMAN (1-724): 0: 1086: 100.00		DYR1B_HUMAN (149-537): 1.88e-118: 366: 39.11
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13
+	Hs
		431548 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCL_HUMAN (38-510): 5.5e-118: 367: 17.08
+	Hs
		431834 HS90A_HUMAN (1-724): 0: 1072: 85.25		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK5_HUMAN (219-541): 2.4e-116: 349: 27.49
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK5_HUMAN (219-541): 2.4e-116: 349: 27.49
+	Hs
		437996 HS90B_HUMAN (1-724): 0: 1086: 100.00		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56
+	Hs
		431655 HS90A_HUMAN (1-724): 0: 1072: 85.25		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56