HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	31980649, 32707033, unassigned2173, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 833
+	Hs
		432128 HS90A_HUMAN (1-724): 0: 1072: 85.25		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		438112 HS90B_HUMAN (1-724): 0: 1086: 100.00		M4K2_HUMAN (7-820): 0: 769: 40.72
+	Hs
		431786 HS90A_HUMAN (1-724): 0: 1072: 85.25		M4K2_HUMAN (7-820): 0: 769: 40.72
+	Hs
		438146 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Mm
		513676 HS90B_MOUSE (1-724): 0: 1089: 99.59		CDKL5_MOUSE (12-589): 1.92e-125: 401: 18.46
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (1-337): 4.68e-131: 401: 23.99
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (1-337): 5.84e-129: 396: 23.12
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (1-337): 6.85e-129: 396: 23.19
+	Hs
		431825 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (10-351): 5.23e-128: 394: 24.29
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (1-337): 6.85e-129: 396: 23.19
+	Hs
		432376 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT3_HUMAN (10-351): 5.23e-128: 394: 24.29
+	Rn
		812703 HS90A_RAT (1-724): 0: 1070: 84.45		AKT1_RAT (1-337): 3.93e-129: 396: 23.12
+	Hs
		131545 HS90B_HUMAN (1-724): 0: 1086: 100.00		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		431792 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK4_HUMAN (4-437): 2.54e-121: 376: 33.10
+	Hs
		131544 HS90A_HUMAN (1-724): 0: 1072: 85.25		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		438348 HS90B_HUMAN (1-724): 0: 1086: 100.00		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58
+	Hs
		432054 HS90A_HUMAN (1-724): 0: 1072: 85.25		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58