HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: KKCC2 (Q96RR4)
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
Gene: CAMKK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 588
+	Hs
		432178 HS90A_HUMAN (1-724): 0: 1072: 85.25		KKCC2_HUMAN (12-588): 3.12e-178: 518: 100.00
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (83-515): 1.49e-132: 397: 22.27
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (83-518): 6.48e-134: 401: 21.90
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (27-515): 1.79e-133: 399: 21.21
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (107-520): 2e-132: 397: 22.86
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (83-515): 8.15e-132: 395: 22.27
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (120-516): 2.77e-126: 388: 23.21
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (64-492): 8.86e-126: 388: 21.04
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (165-568): 4.03e-128: 386: 26.67
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (27-515): 1.79e-133: 399: 21.21
+	Hs
		432376 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT3_HUMAN (107-520): 2e-132: 397: 22.86
+	Hs
		438353 HS90B_HUMAN (1-724): 0: 1086: 100.00		KKCC1_HUMAN (61-536): 2.29e-126: 382: 61.59
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (83-515): 8.15e-132: 395: 22.27
+	Rn
		812703 HS90A_RAT (1-724): 0: 1070: 84.45		AKT1_RAT (83-515): 1.83e-132: 397: 22.05
+	Mm
		432411 HS90A_MOUSE (1-724): 0: 1068: 84.31		AKT1_MOUSE (83-515): 1.49e-132: 397: 22.27
+	Hs
		431548 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCL_HUMAN (120-516): 2.77e-126: 388: 23.21
+	Hs
		431752 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCE_HUMAN (64-492): 8.86e-126: 388: 21.04
+	Hs
		432166 HS90A_HUMAN (1-724): 0: 1072: 85.25		KCC1G_HUMAN (165-568): 4.03e-128: 386: 26.67
+	Hs
		432059 HS90A_HUMAN (1-724): 0: 1072: 85.25		KKCC1_HUMAN (61-536): 2.29e-126: 382: 61.59
+	Sc
		543963 HSC82_YEAST (13-724): 0: 922: 60.22		TOS3_YEAST (125-450): 1.05e-44: 168: 33.99