HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 626
+	Hs
		432200 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		438643 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		432386 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		438350 HS90B_HUMAN (1-724): 0: 1086: 100.00		DCLK2_HUMAN (21-624): 3.27e-138: 422: 16.19
+	Hs
		432057 HS90A_HUMAN (1-724): 0: 1072: 85.25		DCLK2_HUMAN (21-624): 3.27e-138: 422: 16.19
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (40-625): 2e-133: 408: 15.76
+	Hs
		431767 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCD_HUMAN (22-625): 8.67e-139: 421: 17.86
+	Hs
		431762 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCT_HUMAN (40-625): 2e-133: 408: 15.76
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (207-625): 4.47e-126: 389: 18.71
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (247-622): 1.1e-127: 386: 22.40
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (247-622): 1.8e-126: 383: 21.67
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (247-622): 5.15e-127: 384: 21.67
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (291-622): 1.39e-124: 378: 23.08
+	Hs
		431548 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCL_HUMAN (207-625): 4.47e-126: 389: 18.71
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (247-622): 1.1e-127: 386: 22.40
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		432376 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT3_HUMAN (291-622): 1.39e-124: 378: 23.08
+	Hs
		438130 HS90B_HUMAN (1-724): 0: 1086: 100.00		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03
+	Hs
		431808 HS90A_HUMAN (1-724): 0: 1072: 85.25		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03