HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: MKNK1 (Q9BUB5)
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)
Gene: MKNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 465
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (2-439): 3.81e-109: 340: 20.90
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (45-380): 9.09e-110: 328: 18.68
+	Hs
		438148 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC2D_HUMAN (36-455): 1.44e-106: 327: 24.18
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (9-437): 1.32e-106: 326: 21.45
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (45-379): 2.22e-106: 320: 19.60
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (45-380): 9.09e-110: 328: 18.68
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (45-379): 2.22e-106: 320: 19.60
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (23-422): 1.9e-45: 170: 31.77
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (43-452): 4.55e-43: 163: 30.41
+	Hs
		438441 HS90B_HUMAN (1-724): 0: 1086: 100.00		KCC1G_HUMAN (53-376): 7.78e-42: 156: 32.10
+	Hs
		438350 HS90B_HUMAN (1-724): 0: 1086: 100.00		DCLK2_HUMAN (46-381): 5.27e-39: 152: 30.27
+	Hs
		437842 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPSH1_HUMAN (10-394): 3.25e-40: 151: 28.90
+	Hs
		431672 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6A3_HUMAN (43-452): 4.55e-43: 163: 30.41
+	Hs
		431475 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPSH1_HUMAN (10-394): 3.25e-40: 151: 28.90
+	Hs
		270364 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A5_HUMAN (53-404): 8.02e-20: 94.7: 25.75
+	Hs
		438190 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A2_HUMAN (41-373): 7e-19: 91.7: 26.32
+	Hs
		272844 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A4_HUMAN (53-404): 1.36e-18: 90.9: 25.94
+	Hs
		438601 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A6_HUMAN (41-368): 1.23e-18: 90.9: 26.21
+	Hs
		270363 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6A5_HUMAN (53-404): 8.02e-20: 94.7: 25.75
+	Hs
		272843 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6A4_HUMAN (53-404): 1.36e-18: 90.9: 25.94