HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TSSK6 (Q9BXA6)
Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase)
Gene: TSSK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	33961781, 32707033, 22939624, 15870294
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 273
+	Hs
		432225 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK6_HUMAN (1-273): 2.14e-148: 417: 100.00
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (9-272): 6.13e-123: 354: 24.83
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (9-272): 6.13e-123: 354: 24.83
+	Hs
		438443 HS90B_HUMAN (1-724): 0: 1086: 100.00		TSSK3_HUMAN (4-267): 2.65e-83: 252: 49.25
+	Hs
		438442 HS90B_HUMAN (1-724): 0: 1086: 100.00		TSSK2_HUMAN (1-268): 1.39e-79: 246: 46.35
+	Hs
		438490 HS90B_HUMAN (1-724): 0: 1086: 100.00		TSSK1_HUMAN (1-273): 2.18e-79: 245: 46.24
+	Hs
		432170 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK3_HUMAN (4-267): 2.65e-83: 252: 49.25
+	Hs
		432168 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK2_HUMAN (1-268): 1.39e-79: 246: 46.35
+	Hs
		432226 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK1_HUMAN (1-273): 2.18e-79: 245: 46.24
+	Sc
		365561 HSP82_YEAST (12-724): 0: 927: 61.26		SNF1_YEAST (9-268): 1.91e-127: 377: 35.00
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (9-272): 6.13e-123: 354: 24.83
+	Hs
		438641 HS90B_HUMAN (1-724): 0: 1086: 100.00		SIK3_HUMAN (12-272): 1.41e-45: 165: 37.02
+	Hs
		432384 HS90A_HUMAN (1-724): 0: 1072: 85.25		SIK3_HUMAN (12-272): 1.41e-45: 165: 37.02
+	Zm
		35496 A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66		A0A1D6QH07_MAIZE (1-272): 4.76e-130: 378: 30.58
+	Hs
		1123436 H90B4_HUMAN (25-596): 0: 639: 71.85		TSSK6_HUMAN (1-273): 2.14e-148: 417: 100.00
+	Hs
		1162524 Q6PK50_HUMAN (1-350): 0: 618: 99.71		TSSK6_HUMAN (1-273): 2.14e-148: 417: 100.00
+	Hs
		1123432 H90B4_HUMAN (25-596): 0: 639: 71.85		TSSK2_HUMAN (1-268): 1.39e-79: 246: 46.35