HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TSSK1 (Q9BXA7)
Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)
Gene: TSSK1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 367
+	Hs
		438442 HS90B_HUMAN (1-724): 0: 1086: 100.00		TSSK2_HUMAN (1-352): 3.05e-145: 416: 68.27
+	Hs
		432168 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK2_HUMAN (1-352): 3.05e-145: 416: 68.27
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (1-351): 7.23e-134: 399: 24.02
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (4-352): 1.83e-136: 399: 25.92
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (4-349): 4.38e-135: 395: 26.35
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (4-352): 7.69e-136: 397: 25.49
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (4-350): 8.47e-136: 397: 26.27
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (4-349): 6.92e-135: 395: 26.35
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (4-366): 6.4e-133: 390: 23.32
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (4-366): 3.09e-132: 389: 24.40
+	Hs
		431548 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCL_HUMAN (1-351): 7.23e-134: 399: 24.02
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (4-352): 1.83e-136: 399: 25.92
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (4-349): 6.92e-135: 395: 26.35
+	Hs
		432226 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK1_HUMAN (1-367): 1.04e-136: 395: 100.00
+	Hs
		431542 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6B1_HUMAN (4-366): 3.09e-132: 389: 24.40
+	Hs
		438443 HS90B_HUMAN (1-724): 0: 1086: 100.00		TSSK3_HUMAN (7-272): 4.23e-84: 258: 46.99
+	Hs
		438489 HS90B_HUMAN (1-724): 0: 1086: 100.00		TSSK6_HUMAN (1-278): 2.93e-79: 245: 46.24
+	Hs
		432170 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK3_HUMAN (7-272): 4.23e-84: 258: 46.99
+	Hs
		432225 HS90A_HUMAN (1-724): 0: 1072: 85.25		TSSK6_HUMAN (1-278): 2.93e-79: 245: 46.24
+	Hs
		438641 HS90B_HUMAN (1-724): 0: 1086: 100.00		SIK3_HUMAN (12-273): 2.18e-53: 191: 40.91