HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: TRIM8 (Q9BZR9)
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)
Gene: TRIM8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	21689689
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 551
+	Hs
		437880 HS90B_HUMAN (1-724): 0: 1086: 100.00		RO52_HUMAN (1-512): 7.11e-85: 273: 13.90
+	Hs
		438502 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRIM6_HUMAN (1-521): 2.29e-83: 269: 12.84
+	Hs
		438501 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRIM7_HUMAN (10-512): 2.55e-75: 249: 15.28
+	Hs
		432238 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRIM7_HUMAN (10-512): 2.55e-75: 249: 15.28
+	Hs
		437829 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI49_HUMAN (1-510): 7.45e-71: 235: 14.04
+	Hs
		175632 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI18_HUMAN (6-463): 2.85e-71: 242: 16.80
+	Hs
		431456 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI49_HUMAN (1-510): 7.45e-71: 235: 14.04
+	Hs
		438654 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI17_HUMAN (2-513): 6.21e-64: 218: 14.23
+	Hs
		438503 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRIM2_HUMAN (10-495): 3.74e-61: 216: 14.23
+	Hs
		432399 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI17_HUMAN (2-513): 6.21e-64: 218: 14.23
+	Hs
		432239 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRIM2_HUMAN (10-495): 3.74e-61: 216: 14.23
+	Hs
		438549 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI36_HUMAN (6-411): 4.57e-53: 194: 19.13
+	Hs
		432284 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI36_HUMAN (6-411): 4.57e-53: 194: 19.13
+	Hs
		438479 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI56_HUMAN (13-261): 5.59e-42: 162: 26.64
+	Hs
		438500 HS90B_HUMAN (1-724): 0: 1086: 100.00		TRI31_HUMAN (1-318): 4.16e-42: 158: 19.06
+	Hs
		432214 HS90A_HUMAN (1-724): 0: 1072: 85.25		TRI56_HUMAN (13-261): 5.59e-42: 162: 26.64
+	Hs
		62676 ENPL_HUMAN (3-693): 0: 917: 46.44		TRI64_HUMAN (1-510): 1.11e-81: 264: 15.69
+	Hs
		538271 ENPL_HUMAN (3-693): 0: 917: 46.44		TRI68_HUMAN (1-512): 3.24e-78: 256: 12.52
+	Hs
		170238 ENPL_HUMAN (3-693): 0: 917: 46.44		TIF1A_HUMAN (14-531): 9.28e-53: 195: 14.06
+	Hs
		584990 Q6PK50_HUMAN (1-350): 0: 618: 99.71		RO52_HUMAN (1-512): 7.11e-85: 273: 13.90