HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: UN45A (Q9H3U1)
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)
Gene: UNC45A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	18285346, 25036637
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HSP90~TPR_8
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 944
+	Hs
		438336 HS90B_HUMAN (1-724): 0: 1086: 100.00		UN45B_HUMAN (20-939): 0: 905: 56.70
+	Hs
		111940 K9JA46_HUMAN (1-724): 0: 1072: 85.25		UN45B_HUMAN (20-939): 0: 905: 56.70
+	Hs
		438533 HS90B_HUMAN (1-724): 0: 1086: 100.00		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Mm
		513680 HS90B_MOUSE (1-724): 0: 1089: 99.59		PPP5_MOUSE (10-180): 2.35e-39: 155: 23.98
+	Hs
		438021 HS90B_HUMAN (1-724): 0: 1086: 100.00		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		213454 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGTA_HUMAN (1-141): 4.45e-39: 149: 27.66
+	Mm
		513709 HS90B_MOUSE (1-724): 0: 1089: 99.59		CHIP_MOUSE (17-159): 3.41e-35: 138: 29.05
+	Hs
		111935 K9JA46_HUMAN (1-724): 0: 1072: 85.25		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		438621 HS90B_HUMAN (1-724): 0: 1086: 100.00		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		213451 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGTA_HUMAN (1-141): 4.45e-39: 149: 27.66
+	Hs
		438201 HS90B_HUMAN (1-724): 0: 1086: 100.00		TOM34_HUMAN (2-139): 4.73e-31: 126: 27.54
+	Hs
		174561 HS90B_HUMAN (1-724): 0: 1086: 100.00		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		174556 HS90A_HUMAN (1-724): 0: 1072: 85.25		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		437930 HS90B_HUMAN (1-724): 0: 1086: 100.00		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		111934 K9JA46_HUMAN (1-724): 0: 1072: 85.25		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		438590 HS90B_HUMAN (1-724): 0: 1086: 100.00		Z3H7B_HUMAN (21-143): 1.06e-11: 71.2: 33.33
+	Hs
		438598 HS90B_HUMAN (1-724): 0: 1086: 100.00		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93
+	Hs
		297025 HS90B_HUMAN (1-724): 0: 1086: 100.00		TOM70_HUMAN (12-220): 4.6e-09: 62.2: 13.08
+	Hs
		111943 K9JA46_HUMAN (1-724): 0: 1072: 85.25		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93
+	Hs
		297024 HS90A_HUMAN (1-724): 0: 1072: 85.25		TOM70_HUMAN (12-220): 4.6e-09: 62.2: 13.08