HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: PIM2 (Q9P1W9)
Serine/threonine-protein kinase pim-2 (EC 2.7.11.1) (Pim-2h)
Gene: PIM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0043066 - negative regulation of apoptotic process GO:0050821 - protein stabilization
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 311
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (6-307): 1.14e-122: 361: 22.91
+	Hs
		432376 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (6-307): 1.14e-122: 361: 22.91
+	Hs
		432314 HS90A_HUMAN (1-724): 0: 1072: 85.25		PIM2_HUMAN (1-311): 6.03e-125: 361: 100.00
+	Hs
		438323 HS90B_HUMAN (1-724): 0: 1086: 100.00		PIM3_HUMAN (20-294): 2.5e-117: 342: 64.00
+	Hs
		437837 HS90B_HUMAN (1-724): 0: 1086: 100.00		PIM1_HUMAN (6-304): 1.17e-112: 330: 56.29
+	Hs
		432019 HS90A_HUMAN (1-724): 0: 1072: 85.25		PIM3_HUMAN (20-294): 2.5e-117: 342: 64.00
+	Hs
		431471 HS90A_HUMAN (1-724): 0: 1072: 85.25		PIM1_HUMAN (6-304): 1.17e-112: 330: 56.29
+	Sc
		365561 HSP82_YEAST (12-724): 0: 927: 61.26		SNF1_YEAST (19-304): 8.25e-121: 361: 29.35
+	Hs
		538446 ENPL_HUMAN (3-693): 0: 917: 46.44		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Hs
		438557 HS90B_HUMAN (1-724): 0: 1086: 100.00		SNRK_HUMAN (32-295): 5.66e-37: 141: 36.88
+	Zm
		35496 A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66		A0A1D6QH07_MAIZE (21-304): 2.99e-125: 367: 27.18
+	Hs
		1123464 H90B3_HUMAN (1-724): 0: 815: 75.83		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Sc
		366998 HSP82_YEAST (12-724): 0: 927: 61.26		PSK2_YEAST (15-287): 4.86e-45: 165: 34.52
+	Sc
		365941 HSP82_YEAST (12-724): 0: 927: 61.26		PSK1_YEAST (38-286): 3.57e-41: 154: 36.58
+	Hs
		1123447 H90B4_HUMAN (25-596): 0: 639: 71.85		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95
+	Hs
		1162538 Q6PK50_HUMAN (1-350): 0: 618: 99.71		AKT3_HUMAN (1-307): 4.16e-123: 362: 21.95