HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: KS6A6 (Q9UK32)
Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)
Gene: RPS6KA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 745
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (2-743): 0: 786: 71.54
+	Hs
		270364 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A5_HUMAN (52-739): 0: 708: 41.41
+	Hs
		270363 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6A5_HUMAN (52-739): 0: 708: 41.41
+	Hs
		272844 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A4_HUMAN (59-744): 0: 648: 40.39
+	Hs
		272843 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6A4_HUMAN (59-744): 0: 648: 40.39
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (423-727): 1.45e-119: 369: 23.98
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (417-742): 5.02e-118: 365: 24.13
+	Hs
		438633 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT3_HUMAN (411-728): 3.17e-118: 365: 23.33
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (417-742): 1.32e-118: 366: 24.42
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (417-742): 1.91e-117: 363: 24.13
+	Hs
		431573 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT2_HUMAN (423-727): 1.45e-119: 369: 23.98
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (423-738): 1.58e-112: 351: 25.23
+	Hs
		431572 HS90A_HUMAN (1-724): 0: 1072: 85.25		AKT1_HUMAN (417-742): 1.91e-117: 363: 24.13
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (401-738): 7.06e-111: 348: 23.94
+	Hs
		431542 HS90A_HUMAN (1-724): 0: 1072: 85.25		KS6B1_HUMAN (401-738): 7.06e-111: 348: 23.94
+	Hs
		438190 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A2_HUMAN (2-330): 1.75e-100: 327: 23.46
+	Hs
		438541 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK2_HUMAN (424-684): 4.19e-97: 306: 27.21
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (432-675): 1.65e-26: 115: 32.27
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (432-675): 1.65e-26: 115: 32.27