HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: FBXL2 (Q9UKC9)
F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
Gene: FBXL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	22939624, 25036637
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 423
+	Hs
		432349 HS90A_HUMAN (1-724): 0: 1072: 85.25		FBXL2_HUMAN (1-423): 3.12e-84: 265: 100.00
+	Hs
		438345 HS90B_HUMAN (1-724): 0: 1086: 100.00		FXL14_HUMAN (9-421): 2.79e-53: 185: 28.67
+	Hs
		432050 HS90A_HUMAN (1-724): 0: 1072: 85.25		FXL14_HUMAN (9-421): 2.79e-53: 185: 28.67
+	Hs
		438605 HS90B_HUMAN (1-724): 0: 1086: 100.00		FBXL4_HUMAN (132-422): 1.16e-28: 120: 20.72
+	Hs
		432347 HS90A_HUMAN (1-724): 0: 1072: 85.25		FBXL4_HUMAN (132-422): 1.16e-28: 120: 20.72
+	Hs
		432056 HS90A_HUMAN (1-724): 0: 1072: 85.25		FBXL6_HUMAN (180-406): 3.34e-19: 91.6: 20.09
+	Hs
		438362 HS90B_HUMAN (1-724): 0: 1086: 100.00		FXL13_HUMAN (26-199): 6.9e-12: 69.5: 24.71
+	Hs
		438132 HS90B_HUMAN (1-724): 0: 1086: 100.00		SKP2_HUMAN (235-409): 1.36e-09: 61.6: 20.50
+	Hs
		438527 HS90B_HUMAN (1-724): 0: 1086: 100.00		FXL15_HUMAN (80-229): 7.55e-09: 58.5: 23.84
+	Hs
		432071 HS90A_HUMAN (1-724): 0: 1072: 85.25		FXL13_HUMAN (26-199): 6.9e-12: 69.5: 24.71
+	Hs
		431812 HS90A_HUMAN (1-724): 0: 1072: 85.25		SKP2_HUMAN (235-409): 1.36e-09: 61.6: 20.50
+	Hs
		432261 HS90A_HUMAN (1-724): 0: 1072: 85.25		FXL15_HUMAN (80-229): 7.55e-09: 58.5: 23.84
+	Hs
		72080 Q6PK50_HUMAN (1-350): 0: 618: 99.71		B3KM70_HUMAN (1-423): 1.19e-84: 266: 99.76
+	Hs
		1162511 Q6PK50_HUMAN (1-350): 0: 618: 99.71		FXL14_HUMAN (9-421): 2.79e-53: 185: 28.67