HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0032991 - protein-containing complex GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1620
+	Hs
		431435 HS90A_HUMAN (1-724): 0: 1072: 85.25		RET_HUMAN (842-1477): 4.8e-137: 455: 23.56
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (938-1436): 5.66e-129: 429: 25.25
+	Hs
		438189 HS90B_HUMAN (1-724): 0: 1086: 100.00		ERBB4_HUMAN (882-1547): 2.9e-122: 418: 22.24
+	Hs
		437966 HS90B_HUMAN (1-724): 0: 1086: 100.00		ABL2_HUMAN (1103-1526): 1.55e-118: 405: 32.47
+	Hs
		437897 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31
+	Hs
		169160 HS90B_HUMAN (1-724): 0: 1086: 100.00		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		435497 HS90B_HUMAN (1-724): 0: 1086: 100.00		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		169159 HS90A_HUMAN (1-724): 0: 1072: 85.25		MUSK_HUMAN (983-1391): 2.02e-118: 396: 29.98
+	Hs
		431472 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06
+	Hs
		438167 HS90B_HUMAN (1-724): 0: 1086: 100.00		FAK2_HUMAN (1054-1518): 4.66e-109: 374: 27.45
+	Hs
		431438 HS90A_HUMAN (1-724): 0: 1072: 85.25		IGF1R_HUMAN (1037-1385): 8.86e-111: 386: 39.77
+	Hs
		437855 HS90B_HUMAN (1-724): 0: 1086: 100.00		INSRR_HUMAN (1082-1384): 2.38e-70: 262: 43.46
+	Hs
		438213 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44
+	Hs
		384122 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		437867 HS90B_HUMAN (1-724): 0: 1086: 100.00		FER_HUMAN (1101-1377): 1.53e-59: 223: 40.35
+	Hs
		438205 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK3_HUMAN (1093-1375): 2.69e-59: 223: 39.03
+	Hs
		426937 HS90B_HUMAN (1-724): 0: 1086: 100.00		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80
+	Hs
		384111 HS90A_HUMAN (1-724): 0: 1072: 85.25		NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07
+	Hs
		426936 HS90A_HUMAN (1-724): 0: 1072: 85.25		FES_HUMAN (1114-1384): 4.5e-59: 222: 42.80