HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: CILK1 (Q9UPZ9)
Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Ciliogenesis associated kinase 1) (Intestinal cell kinase) (hICK) (Laryngeal cancer kinase 2) (LCK2) (MAK-related kinase) (MRK)
Gene: CILK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	32707033, 22939624
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 632
+	Hs
		432369 HS90A_HUMAN (1-724): 0: 1072: 85.25		CILK1_HUMAN (1-632): 0: 558: 100.00
+	Hs
		72111 HS90A_HUMAN (1-724): 0: 1072: 85.25		B3KQG4_HUMAN (1-632): 0: 558: 99.84
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK3_HUMAN (1-295): 6.17e-142: 416: 38.59
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK3_HUMAN (1-295): 6.17e-142: 416: 38.59
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1086: 100.00		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK1_HUMAN (1-289): 3.13e-136: 401: 39.93
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1072: 85.25		CDK5_HUMAN (1-290): 1.44e-131: 389: 33.79
+	Hs
		538107 ENPL_HUMAN (3-693): 0: 917: 46.44		CDK2_HUMAN (1-290): 1.28e-143: 420: 38.91
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 929: 62.48		CDK1_SCHPO (1-288): 4.61e-122: 365: 37.92
+	Hs
		72113 Q6PK50_HUMAN (1-350): 0: 618: 99.71		B3KQG4_HUMAN (1-632): 0: 558: 99.84
+	Hs
		960099 H90B4_HUMAN (25-596): 0: 639: 71.85		CDK3_HUMAN (1-295): 6.17e-142: 416: 38.59
+	Hs
		960137 H90B3_HUMAN (1-724): 0: 815: 75.83		CDKL1_HUMAN (1-285): 4.6e-58: 201: 38.28
+	Hs
		960136 H90B4_HUMAN (25-596): 0: 639: 71.85		CDKL1_HUMAN (1-285): 4.6e-58: 201: 38.28