HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 479
+	Mm
		513660 HS90B_MOUSE (1-724): 0: 1089: 99.59		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Hs
		437928 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Bt
		964601 HS90B_BOVIN (1-724): 0: 1085: 99.59		AKT1_BOVIN (1-476): 0: 561: 81.84
+	Hs
		437927 HS90B_HUMAN (1-724): 0: 1086: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		437869 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		437907 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCL_HUMAN (110-476): 8.45e-151: 447: 41.73
+	Hs
		438085 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCE_HUMAN (52-473): 1.57e-148: 443: 41.41
+	Hs
		408529 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		437905 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		438094 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCT_HUMAN (85-479): 8.26e-147: 437: 39.39
+	Hs
		438422 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		431510 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		438585 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		116958 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		408527 HS90A_HUMAN (1-724): 0: 1072: 85.25		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		438541 HS90B_HUMAN (1-724): 0: 1086: 100.00		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Hs
		116956 HS90A_HUMAN (1-724): 0: 1072: 85.25		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		438193 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		438011 HS90B_HUMAN (1-724): 0: 1086: 100.00		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		437962 HS90B_HUMAN (1-724): 0: 1086: 100.00		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94