HitPredict

Interactor 1: MMP2 (P08253)
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
Gene: MMP2

Interactor 2: COIA1 (P39060)
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
Gene: COL18A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	28514442, 33961781, 17615292
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0009410 - response to xenobiotic stimulus GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 660 Hs			1 1754
+	Hs
		540418 MMP9_HUMAN (21-660): 0: 711: 44.40		COIA1_HUMAN (1-1754): 0: 1036: 99.60
+	Hs
		358647 MMP2_HUMAN (1-660): 0: 912: 100.00		CO4A1_HUMAN (783-1673): 7.78e-70: 262: 22.25
+	Hs
		439220 MMP2_HUMAN (1-660): 0: 912: 100.00		CO4A2_HUMAN (875-1671): 4.08e-60: 231: 24.21
+	Hs
		358587 MMP2_HUMAN (1-660): 0: 912: 100.00		CO2A1_HUMAN (1236-1673): 2.7e-27: 123: 17.83
+	Hs
		439240 MMP2_HUMAN (1-660): 0: 912: 100.00		CO4A6_HUMAN (1192-1673): 6.92e-26: 118: 18.92
+	Hs
		436001 MMP2_HUMAN (1-660): 0: 912: 100.00		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		358454 MMP2_HUMAN (1-660): 0: 912: 100.00		CO1A1_HUMAN (614-901): 6.51e-11: 70.1: 24.83
+	Hs
		358650 MMP9_HUMAN (21-660): 0: 711: 44.40		CO4A1_HUMAN (783-1673): 7.78e-70: 262: 22.25
+	Hs
		441053 MMP9_HUMAN (21-660): 0: 711: 44.40		CO4A2_HUMAN (875-1671): 4.08e-60: 231: 24.21
+	Hs
		358595 MMP9_HUMAN (21-660): 0: 711: 44.40		CO2A1_HUMAN (1236-1673): 2.7e-27: 123: 17.83
+	Hs
		436005 MMP9_HUMAN (21-660): 0: 711: 44.40		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		436002 MMP3_HUMAN (18-229): 4.24e-90: 290: 44.95		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		372723 MMP1_HUMAN (34-230): 8.32e-84: 273: 42.11		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		436012 MMP8_HUMAN (42-230): 4.19e-78: 258: 41.50		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		436025 MMP16_HUMAN (50-229): 1.38e-71: 244: 35.78		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		436022 MMP14_HUMAN (51-519): 6.63e-70: 239: 21.09		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		436024 MMP15_HUMAN (41-229): 7.87e-69: 238: 33.80		CO1A2_HUMAN (1454-1666): 9.11e-12: 72.8: 9.29
+	Hs
		363093 FINC_HUMAN (255-405): 8.74e-31: 131: 42.24		CO7A1_HUMAN (1243-1619): 3.63e-23: 110: 19.90
+	Hs
		358441 FINC_HUMAN (255-405): 8.74e-31: 131: 42.24		CO1A1_HUMAN (614-901): 6.51e-11: 70.1: 24.83