HitPredict

Interactor 1: MMP2 (P08253)
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
Gene: MMP2

Interactor 2: EDA (Q92838)
Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form]
Gene: EDA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 660 Hs			1 391
+	Hs
		439222 MMP2_HUMAN (1-660): 0: 912: 100.00		CO6A2_HUMAN (1-187): 3.55e-26: 112: 12.34
+	Hs
		439221 MMP2_HUMAN (1-660): 0: 912: 100.00		CO6A1_HUMAN (1-192): 5.99e-26: 111: 13.98
+	Hs
		358587 MMP2_HUMAN (1-660): 0: 912: 100.00		CO2A1_HUMAN (50-295): 6.46e-11: 66.4: 16.73
+	Hs
		439220 MMP2_HUMAN (1-660): 0: 912: 100.00		CO4A2_HUMAN (2-143): 2.12e-10: 64.5: 12.50
+	Hs
		439240 MMP2_HUMAN (1-660): 0: 912: 100.00		CO4A6_HUMAN (37-300): 2.35e-10: 64.5: 15.46
+	Hs
		439227 MMP2_HUMAN (1-660): 0: 912: 100.00		CO5A1_HUMAN (107-242): 6e-09: 60.1: 25.93
+	Hs
		358647 MMP2_HUMAN (1-660): 0: 912: 100.00		CO4A1_HUMAN (41-306): 8.93e-09: 59.5: 16.61
+	Hs
		517985 MMP9_HUMAN (21-660): 0: 711: 44.40		CO6A2_HUMAN (1-187): 3.55e-26: 112: 12.34
+	Hs
		517917 MMP9_HUMAN (21-660): 0: 711: 44.40		CO6A1_HUMAN (1-192): 5.99e-26: 111: 13.98
+	Hs
		358595 MMP9_HUMAN (21-660): 0: 711: 44.40		CO2A1_HUMAN (50-295): 6.46e-11: 66.4: 16.73
+	Hs
		441053 MMP9_HUMAN (21-660): 0: 711: 44.40		CO4A2_HUMAN (2-143): 2.12e-10: 64.5: 12.50
+	Hs
		540415 MMP9_HUMAN (21-660): 0: 711: 44.40		CO5A1_HUMAN (107-242): 6e-09: 60.1: 25.93
+	Hs
		358650 MMP9_HUMAN (21-660): 0: 711: 44.40		CO4A1_HUMAN (41-306): 8.93e-09: 59.5: 16.61
+	Hs
		362808 FINC_HUMAN (255-405): 8.74e-31: 131: 42.24		CO9A1_HUMAN (2-270): 7.2e-11: 66.1: 19.17
+	Hs
		363093 FINC_HUMAN (255-405): 8.74e-31: 131: 42.24		CO7A1_HUMAN (77-303): 4.39e-09: 60.7: 18.30
+	Hs
		362809 FINC_HUMAN (255-405): 8.74e-31: 131: 42.24		CO5A1_HUMAN (107-242): 6e-09: 60.1: 25.93
+	Hs
		70534 MRC2_HUMAN (209-275): 1.44e-19: 95.9: 38.81		C1T9B_HUMAN (2-167): 2.68e-15: 78: 13.97