HitPredict

Interactor 1: MMP3 (P08254)
Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
Gene: MMP3

Interactor 2: TIMP2 (P16035)
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Gene: TIMP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12475252
Identification Methods	surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008270 - zinc ion binding GO:0031012 - extracellular matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 477 Hs			1 220
+	Hs
		439275 MMP3_HUMAN (1-477): 0: 676: 100.00		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		439265 MMP3_HUMAN (1-477): 0: 676: 100.00		TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19
+	Hs
		372726 MMP1_HUMAN (14-477): 0: 615: 53.55		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		344781 MMP3_HUMAN (1-477): 0: 676: 100.00		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		372742 MMP1_HUMAN (14-477): 0: 615: 53.55		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		344784 MMP10_HUMAN (1-477): 0: 648: 77.99		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Mm
		706099 MMP13_MOUSE (3-477): 0: 625: 49.06		TIMP3_MOUSE (10-220): 1.95e-92: 271: 43.72
+	Hs
		554810 MMP16_HUMAN (6-477): 0: 573: 35.37		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		554808 MMP14_HUMAN (34-477): 0: 559: 38.21		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		344777 MMP1_HUMAN (14-477): 0: 615: 53.55		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		838537 MMP14_HUMAN (34-477): 0: 559: 38.21		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		554809 MMP15_HUMAN (34-477): 0: 544: 34.96		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		726505 MMP14_HUMAN (34-477): 0: 559: 38.21		TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19
+	Hs
		344795 MMP14_HUMAN (34-477): 0: 559: 38.21		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		439223 MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		439254 MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55		TIMP4_HUMAN (24-220): 3.3e-107: 309: 49.75
+	Hs
		540409 MMP9_HUMAN (13-204): 2.95e-71: 241: 45.77		TIMP2_HUMAN (1-220): 2.84e-111: 319: 100.00
+	Hs
		439230 MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55		TIMP3_HUMAN (10-220): 1.96e-95: 278: 44.19
+	Hs
		344780 MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29
+	Hs
		344786 MMP9_HUMAN (13-204): 2.95e-71: 241: 45.77		TIMP1_HUMAN (10-203): 5.81e-86: 255: 42.29