HitPredict

Interactor 1: KCC2B (P08413)
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
Gene: Camk2b

Interactor 2: TAU (P19332)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: Mapt

Species: Rattus norvegicus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	32357304
Identification Methods	cross-linking study
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010976 - positive regulation of neuron projection development GO:0014069 - postsynaptic density GO:0019901 - protein kinase binding and 2 others more... GO:0030425 - dendrite GO:0043005 - neuron projection
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 542 Rn			1 752
+	Rn
		94121 KCC2B_RAT (1-542): 0: 626: 100.00		F1LST4_RAT (1-751): 5.68e-95: 314: 99.87
+	Rn
		514946 KCC2G_RAT (1-542): 0: 589: 83.40		TAU_RAT (1-752): 2.4e-95: 314: 100.00
+	Rn
		94132 KCC2G_RAT (1-542): 0: 589: 83.40		F1LST4_RAT (1-751): 5.68e-95: 314: 99.87
+	Mm
		498111 KCC2G_MOUSE (1-542): 0: 591: 81.37		TAU_MOUSE (1-752): 1.92e-82: 279: 89.52
+	Hs
		92372 E9PBG7_HUMAN (1-542): 0: 588: 80.63		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Rn
		506692 KCC2A_RAT (3-538): 2.06e-161: 469: 63.43		TAU_RAT (1-752): 2.4e-95: 314: 100.00
+	Rn
		94129 KCC2A_RAT (3-538): 2.06e-161: 469: 63.43		F1LST4_RAT (1-751): 5.68e-95: 314: 99.87
+	Hs
		496977 KCC2D_HUMAN (1-542): 9.73e-169: 489: 64.76		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		497824 KCC2A_HUMAN (3-538): 1.97e-161: 469: 63.43		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Mm
		592770 KCC2D_MOUSE (1-542): 9.73e-169: 489: 64.76		MTAP2_MOUSE (49-752): 4.26e-36: 149: 25.07
+	Rn
		506773 KCC2A_RAT (3-538): 2.06e-161: 469: 63.43		PCLO_RAT (1-751): 2.97e-14: 79.3: 9.20
+	Hs
		159141 CSKP_HUMAN (10-308): 5.78e-84: 281: 46.73		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		496976 KCC2B_HUMAN (279-542): 4.04e-45: 170: 52.65		TAU_HUMAN (1-752): 2.05e-72: 253: 71.86
+	Hs
		1083233 KCC4_HUMAN (10-304): 1.6e-70: 235: 42.76		CABIN_HUMAN (103-561): 3.85e-12: 72.2: 12.26