HitPredict

Interactor 1: ITA2B (P08514)
Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
Gene: ITGA2B

Interactor 2: ITA2B (P08514)
Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2]
Gene: ITGA2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.872

The method score is based on:

Property Details
Experiments 15067009, 11606749, 14681217
Identification Methods tox-r dimerization assay, comigration in non denaturing gel electrophoresis, cosedimentation in solution, lex-a dimerization assay
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FG-GAP~FG-GAP, FG-GAP~Integrin_alpha2, Integrin_alpha2~Integrin_alpha2
Common GO terms GO:0001525 - angiogenesis
GO:0002687 - positive regulation of leukocyte migration
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 14 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1039
Hs

1 1039
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024