HitPredict

Interactor 1: ODPA (P08559)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
Gene: PDHA1

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	26186194, 24486017, 22195962, 29568061, 34079125, 7782287
Identification Methods	affinity chromatography technology, pull down, enzymatic study, proximity labelling technology
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006006 - glucose metabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 390 Hs			1 436
+	Hs
		440533 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		PDK4_HUMAN (23-433): 0: 608: 64.72
+	Hs
		440524 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		PDK2_HUMAN (37-436): 0: 604: 69.25
+	Hs
		669776 ODPAT_HUMAN (4-390): 2.34e-177: 500: 85.27		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Hs
		440525 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Hs
		520709 ODBA_HUMAN (3-386): 4.22e-134: 392: 24.17		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		969481 ODO1_HUMAN (2-366): 2.85e-125: 387: 14.75		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		157284 ODPA_HUMAN (1-390): 4.58e-177: 499: 100.00		BCKD_HUMAN (1-398): 1.26e-164: 471: 28.97
+	Hs
		157289 ODBA_HUMAN (3-386): 4.22e-134: 392: 24.17		BCKD_HUMAN (1-398): 1.26e-164: 471: 28.97
+	Sc
		558637 ODPA_YEAST (42-383): 1.18e-149: 431: 52.01		PDK1_YEAST (46-397): 8.85e-119: 353: 24.66