HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PSI~ig
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016020 - membrane and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 1106
+	Hs
		441513 MET_HUMAN (1-1390): 0: 1283: 100.00		NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58
+	Mm
		555013 MET_MOUSE (1-1381): 0: 1246: 89.57		NTRK3_MOUSE (285-966): 1.3e-128: 414: 17.04
+	Hs
		441410 MET_HUMAN (1-1390): 0: 1283: 100.00		FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44
+	Mm
		554963 MET_MOUSE (1-1381): 0: 1246: 89.57		VGFR2_MOUSE (16-525): 1.14e-71: 263: 19.86
+	Hs
		441498 MET_HUMAN (1-1390): 0: 1283: 100.00		PTK7_HUMAN (28-630): 9.12e-42: 168: 12.58
+	Hs
		441431 MET_HUMAN (1-1390): 0: 1283: 100.00		FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73
+	Hs
		441451 MET_HUMAN (1-1390): 0: 1283: 100.00		VGFR2_HUMAN (10-197): 4.73e-11: 69.5: 11.31
+	Hs
		557076 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		PGFRA_HUMAN (3-1106): 0: 716: 42.48
+	Hs
		557034 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		PGFRA_HUMAN (3-1106): 0: 716: 42.48
+	Hs
		665676 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		EPHA6_HUMAN (65-1006): 1.05e-174: 542: 14.44
+	Hs
		872587 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		EPHA6_HUMAN (65-1006): 1.05e-174: 542: 14.44
+	Hs
		1072506 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58
+	Hs
		507926 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44
+	Hs
		601484 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		FGFR2_HUMAN (9-326): 2.34e-58: 218: 11.51
+	Hs
		609225 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		FGFR3_HUMAN (1-313): 7.09e-52: 198: 10.66
+	Hs
		607929 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73
+	Hs
		507857 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44
+	Hs
		607974 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		FGFR4_HUMAN (200-413): 5.32e-14: 78.7: 17.73
+	Hs
		426988 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		CSF1R_HUMAN (10-385): 7.2e-13: 75.3: 12.97
+	Hs
		426999 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		CSF1R_HUMAN (10-385): 7.2e-13: 75.3: 12.97