HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.908

Property	Details
Experiments	24728074, 9837958, 20624308, 35405500, 24034250
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 536
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (1-535): 0: 583: 65.99
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (1-531): 0: 569: 55.22
+	Mm
		554964 MET_MOUSE (1-1381): 0: 1246: 89.57		FYN_MOUSE (1-536): 0: 597: 68.58
+	Hs
		411558 MET_HUMAN (1-1390): 0: 1283: 100.00		LCK_HUMAN (75-534): 0: 552: 58.48
+	Hs
		433529 MET_HUMAN (1-1390): 0: 1283: 100.00		LYN_HUMAN (1-531): 0: 532: 52.44
+	Hs
		441471 MET_HUMAN (1-1390): 0: 1283: 100.00		BLK_HUMAN (45-531): 1.62e-179: 516: 57.58
+	Hs
		441462 MET_HUMAN (1-1390): 0: 1283: 100.00		ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03
+	Hs
		441493 MET_HUMAN (1-1390): 0: 1283: 100.00		ITK_HUMAN (54-525): 1.53e-160: 472: 34.23
+	Hs
		441461 MET_HUMAN (1-1390): 0: 1283: 100.00		TXK_HUMAN (13-526): 7.51e-161: 469: 34.55
+	Hs
		441460 MET_HUMAN (1-1390): 0: 1283: 100.00		TEC_HUMAN (83-528): 6.43e-155: 458: 37.36
+	Hs
		441489 MET_HUMAN (1-1390): 0: 1283: 100.00		BTK_HUMAN (43-527): 1.18e-154: 458: 34.35
+	Hs
		441500 MET_HUMAN (1-1390): 0: 1283: 100.00		PTK6_HUMAN (81-529): 3.9e-155: 452: 43.83
+	Hs
		522802 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		SRC_HUMAN (1-536): 0: 651: 100.00
+	Hs
		412036 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		412104 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		FYN_HUMAN (1-536): 0: 598: 68.39
+	Mm
		763386 EPHA4_MOUSE (555-1389): 1.3e-175: 550: 17.08		FYN_MOUSE (1-536): 0: 597: 68.58
+	Hs
		433602 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		LYN_HUMAN (1-531): 0: 532: 52.44
+	Hs
		337359 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00
+	Mm
		337625 EPHA4_MOUSE (555-1389): 1.3e-175: 550: 17.08		ABL1_MOUSE (47-536): 4.29e-169: 509: 40.00