HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: HGF (P14210)
Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
Gene: HGF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 18593464, 28205554, 1655405, 8380735, 19433454, 20624990, 16537482, 17804794, 15167892, 17981115, 22897854, 1846706
Identification Methods unspecified method, fluorescent resonance energy transfer, affinity chromatography technology, pull down, enzymatic study, amplified luminescent proximity homogeneous assay, x ray scattering, x-ray crystallography, enzyme linked immunosorbent assay, saturation binding and 1 others

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Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Kringle~PSI, Kringle~Sema
Common GO terms GO:0001889 - liver development
GO:0005576 - extracellular region
GO:0010507 - negative regulation of autophagy
GO:0016020 - membrane
GO:0045944 - positive regulation of transcription by RNA polymerase II
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1390
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Last updated: 15 Jul 2024