HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016477 - cell migration GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 377
+	Hs
		208977 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		441460 MET_HUMAN (1-1390): 0: 1283: 100.00		TEC_HUMAN (27-377): 4.7e-38: 146: 17.63
+	Hs
		441462 MET_HUMAN (1-1390): 0: 1283: 100.00		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Hs
		441439 MET_HUMAN (1-1390): 0: 1283: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129172 MET_HUMAN (1-1390): 0: 1283: 100.00		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (7-150): 8.06e-20: 92.9: 20.00
+	Hs
		441415 MET_HUMAN (1-1390): 0: 1283: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		441477 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		441580 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV3_HUMAN (1-58): 1.16e-12: 71.4: 24.59
+	Mm
		554991 MET_MOUSE (1-1381): 0: 1246: 89.57		SRBS2_MOUSE (46-288): 1.38e-24: 107: 18.85
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		441550 MET_HUMAN (1-1390): 0: 1283: 100.00		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Mm
		554964 MET_MOUSE (1-1381): 0: 1246: 89.57		FYN_MOUSE (7-173): 7.13e-21: 96: 15.39
+	Mm
		101586 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03
+	Hs
		924497 RON_HUMAN (23-1390): 0: 934: 32.70		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		655220 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129209 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		412036 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		522802 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32