HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: PTPRB (P23467)
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Gene: PTPRB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16101282
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 1997
+	Mm
		56905 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRF_MOUSE (1637-1964): 1.5e-87: 321: 33.13
+	Mm
		554958 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRA_MOUSE (1683-1966): 1.22e-48: 190: 35.29
+	Hs
		441164 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		441515 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46
+	Hs
		441434 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60
+	Hs
		441494 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75
+	Hs
		441507 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10
+	Mm
		554962 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRK_MOUSE (6-325): 2.33e-19: 97.7: 15.30
+	Hs
		981901 RON_HUMAN (23-1390): 0: 934: 32.70		TITIN_HUMAN (903-1102): 2.88e-09: 65: 11.52
+	Hs
		441184 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRC_HUMAN (1703-1975): 3.32e-25: 117: 27.67
+	Hs
		617082 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRG_HUMAN (1727-1968): 6.3e-23: 109: 29.60
+	Hs
		725305 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRJ_HUMAN (1245-1617): 2.86e-16: 87.8: 15.75
+	Hs
		576991 RYK_HUMAN (1078-1334): 2.54e-59: 218: 39.47		PTPRA_HUMAN (1687-1966): 2.17e-103: 353: 35.23
+	Hs
		987281 TYRO3_HUMAN (1053-1341): 6.19e-65: 240: 41.67		COCA1_HUMAN (374-1717): 1.46e-83: 309: 11.03
+	Hs
		234508 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		DSCAM_HUMAN (2-661): 1.06e-64: 246: 12.72
+	Hs
		616946 RYK_HUMAN (1078-1334): 2.54e-59: 218: 39.47		PTPRD_HUMAN (902-1709): 1.7e-69: 262: 12.33
+	Hs
		850472 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10
+	Hs
		489910 RYK_HUMAN (1078-1334): 2.54e-59: 218: 39.47		PTPRF_HUMAN (905-1707): 2.85e-67: 255: 10.82
+	Hs
		165205 PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57		PTPRO_HUMAN (41-479): 4.06e-24: 113: 14.46
+	Hs
		165200 PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57		PTPRK_HUMAN (262-866): 9.73e-16: 85.8: 10.10