HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24728074, 9660480
Identification Methods	pull down, affinity chromatography technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 583
+	Hs
		441524 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC4_HUMAN (7-581): 1.07e-136: 413: 45.53
+	Hs
		441545 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47
+	Hs
		441481 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC2_HUMAN (56-582): 4.56e-116: 358: 44.88
+	Hs
		441502 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41
+	Hs
		441580 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV3_HUMAN (190-579): 2.86e-47: 179: 14.52
+	Hs
		441554 MET_HUMAN (1-1390): 0: 1283: 100.00		SHD_HUMAN (328-582): 1.62e-47: 171: 23.02
+	Hs
		208977 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		441472 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		441510 MET_HUMAN (1-1390): 0: 1283: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		441537 MET_HUMAN (1-1390): 0: 1283: 100.00		SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55
+	Hs
		441422 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		275527 MET_HUMAN (1-1390): 0: 1283: 100.00		BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83
+	Hs
		441439 MET_HUMAN (1-1390): 0: 1283: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		426938 MET_HUMAN (1-1390): 0: 1283: 100.00		FES_HUMAN (326-581): 1.46e-37: 150: 21.79
+	Hs
		441503 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57
+	Hs
		441546 MET_HUMAN (1-1390): 0: 1283: 100.00		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129172 MET_HUMAN (1-1390): 0: 1283: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		441477 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		101586 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48