HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29880877
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction GO:0061436 - establishment of skin barrier
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 248
+	Hs
		441479 MET_HUMAN (1-1390): 0: 1283: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Mm
		554972 MET_MOUSE (1-1381): 0: 1246: 89.57		1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96
+	Mm
		554970 MET_MOUSE (1-1381): 0: 1246: 89.57		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Hs
		683980 RON_HUMAN (23-1390): 0: 934: 32.70		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		909466 RON_HUMAN (23-1390): 0: 934: 32.70		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		926953 RON_HUMAN (23-1390): 0: 934: 32.70		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646822 RON_HUMAN (23-1390): 0: 934: 32.70		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683284 RON_HUMAN (23-1390): 0: 934: 32.70		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		904469 RON_HUMAN (23-1390): 0: 934: 32.70		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		981860 RON_HUMAN (23-1390): 0: 934: 32.70		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	At
		965369 CLV1_ARATH (565-1339): 0: 566: 14.48		14332_ARATH (3-248): 2.23e-144: 405: 58.47
+	Zm
		22560 A0A1D6I257_MAIZE (521-1346): 7.87e-180: 562: 14.21		B6U284_MAIZE (1-247): 1.9e-145: 408: 57.43
+	Hs
		601493 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		909494 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		609187 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		601470 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		674386 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646846 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683304 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		674348 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62