HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21325980
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 840
+	Mm
		555006 MET_MOUSE (1-1381): 0: 1246: 89.57		HS105_MOUSE (1-840): 0: 932: 61.56
+	Hs
		1072565 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		609191 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320811 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		337370 ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		714124 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320797 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		320795 INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		411458 INSR_HUMAN (1084-1335): 3.87e-55: 213: 42.11		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		503944 RON_HUMAN (23-1390): 0: 934: 32.70		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503499 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503438 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503517 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564014 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		165150 PLXB2_HUMAN (365-1012): 1.26e-58: 225: 16.57		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		435511 IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Rn
		544811 INSR_RAT (1084-1335): 3.22e-52: 204: 40.98		HSP7C_RAT (564-692): 1.76e-19: 95.5: 16.15
+	Hs
		337324 ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503596 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		564025 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86