HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24728074, 24828152
Identification Methods	pull down, affinity chromatography technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016020 - membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 304
+	Hs
		441580 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15
+	Hs
		441472 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		441428 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		441423 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		441477 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		208977 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Mm
		101586 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		441422 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		441550 MET_HUMAN (1-1390): 0: 1283: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Hs
		580981 RON_HUMAN (23-1390): 0: 934: 32.70		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		924497 RON_HUMAN (23-1390): 0: 934: 32.70		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		1144837 Q8BRB1_MOUSE (584-1382): 0: 566: 18.18		CRK_MOUSE (1-304): 5.53e-68: 215: 99.67
+	Hs
		665378 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802810 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		665389 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		580965 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562635 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		872422 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557643 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		209018 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00