HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17353931
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 245
+	Mm
		554972 MET_MOUSE (1-1381): 0: 1246: 89.57		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Hs
		441444 MET_HUMAN (1-1390): 0: 1283: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Mm
		554970 MET_MOUSE (1-1381): 0: 1246: 89.57		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Hs
		926953 RON_HUMAN (23-1390): 0: 934: 32.70		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		909466 RON_HUMAN (23-1390): 0: 934: 32.70		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		646822 RON_HUMAN (23-1390): 0: 934: 32.70		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683284 RON_HUMAN (23-1390): 0: 934: 32.70		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		904469 RON_HUMAN (23-1390): 0: 934: 32.70		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		981860 RON_HUMAN (23-1390): 0: 934: 32.70		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		683980 RON_HUMAN (23-1390): 0: 934: 32.70		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	At
		965369 CLV1_ARATH (565-1339): 0: 566: 14.48		14332_ARATH (3-239): 6.89e-143: 401: 65.15
+	Zm
		22560 A0A1D6I257_MAIZE (521-1346): 7.87e-180: 562: 14.21		B6U284_MAIZE (1-241): 1.06e-142: 401: 63.27
+	Hs
		601493 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		609187 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		601470 FGFR2_HUMAN (1029-1379): 3.01e-105: 355: 33.15		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		909494 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		674386 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		646846 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		683304 MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		674348 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60