HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.80	0.579

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 780
+	Hs
		441164 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		441433 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		441425 MET_HUMAN (1-1390): 0: 1283: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		441488 MET_HUMAN (1-1390): 0: 1283: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Mm
		554958 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRA_MOUSE (7-295): 2.45e-106: 346: 32.08
+	Mm
		56905 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRF_MOUSE (3-299): 2.35e-91: 316: 32.01
+	Hs
		441507 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		441434 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Mm
		554962 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRK_MOUSE (17-297): 1.84e-59: 221: 26.64
+	Hs
		441515 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		441494 MET_HUMAN (1-1390): 0: 1283: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		441184 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		573629 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Hs
		872429 EPHA5_HUMAN (579-1346): 3.64e-177: 556: 19.08		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		872635 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		985961 EPHA7_HUMAN (587-1389): 6.03e-156: 498: 18.53		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		609260 FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		617082 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		725305 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		850472 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64