HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24728074, 34718347
Identification Methods	pull down, affinity chromatography technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 532
+	Hs
		441502 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB14_HUMAN (12-532): 0: 614: 47.91
+	Hs
		441472 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV2_HUMAN (81-526): 4.93e-78: 264: 14.77
+	Hs
		441580 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Hs
		411558 MET_HUMAN (1-1390): 0: 1283: 100.00		LCK_HUMAN (317-527): 2.74e-57: 200: 20.00
+	Hs
		441493 MET_HUMAN (1-1390): 0: 1283: 100.00		ITK_HUMAN (232-527): 1.19e-54: 196: 18.10
+	Hs
		441428 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		441489 MET_HUMAN (1-1390): 0: 1283: 100.00		BTK_HUMAN (192-529): 1.31e-48: 180: 13.86
+	Hs
		433529 MET_HUMAN (1-1390): 0: 1283: 100.00		LYN_HUMAN (347-531): 4.7e-49: 178: 18.46
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (345-527): 5.44e-48: 176: 21.65
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		441415 MET_HUMAN (1-1390): 0: 1283: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (349-527): 4.62e-45: 168: 19.37
+	Hs
		441565 MET_HUMAN (1-1390): 0: 1283: 100.00		SLAP2_HUMAN (355-528): 3.54e-42: 153: 19.55
+	Mm
		554964 MET_MOUSE (1-1381): 0: 1246: 89.57		FYN_MOUSE (357-529): 5.57e-50: 182: 20.88
+	Hs
		441459 MET_HUMAN (1-1390): 0: 1283: 100.00		MATK_HUMAN (398-525): 4.78e-36: 142: 30.37
+	Hs
		441466 MET_HUMAN (1-1390): 0: 1283: 100.00		KSYK_HUMAN (412-531): 6.62e-17: 86: 30.00
+	Hs
		441477 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Mm
		101586 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GRB2_MOUSE (427-513): 2.66e-13: 71: 29.89
+	Hs
		580981 RON_HUMAN (23-1390): 0: 934: 32.70		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		924497 RON_HUMAN (23-1390): 0: 934: 32.70		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89