HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: CEA21 (Q3KPI0)
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene: CEACAM21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Sema~V-set, TIG~V-set
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1390 Hs			1 293
+	Hs
		441555 MET_HUMAN (1-1390): 0: 1283: 100.00		LRIG1_HUMAN (5-283): 4.14e-39: 147: 16.14
+	Mm
		554963 MET_MOUSE (1-1381): 0: 1246: 89.57		VGFR2_MOUSE (47-277): 1e-11: 67.5: 12.05
+	Mm
		56905 MET_MOUSE (1-1381): 0: 1246: 89.57		PTPRF_MOUSE (25-173): 8.15e-10: 61.8: 16.78
+	Hs
		981901 RON_HUMAN (23-1390): 0: 934: 32.70		TITIN_HUMAN (62-258): 8.3e-09: 58.7: 13.89
+	Hs
		665402 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Hs
		872657 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Hs
		725306 TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00		PSG5_HUMAN (4-242): 7.76e-23: 98: 16.60
+	Hs
		685227 EPHB4_HUMAN (736-1342): 2.91e-128: 424: 21.72		CEAM8_HUMAN (5-253): 2.17e-20: 91.4: 15.56
+	Hs
		685223 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		CEAM8_HUMAN (5-253): 2.17e-20: 91.4: 15.56
+	Hs
		713814 RYK_HUMAN (1078-1334): 2.54e-59: 218: 39.47		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Dm
		332157 O96681_DROME (459-1070): 1.68e-82: 301: 20.72		PTK7_DROME (84-286): 1.03e-17: 85.1: 21.33
+	Hs
		1070999 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		LRIG1_HUMAN (5-283): 4.14e-39: 147: 16.14
+	Hs
		713822 RYK_HUMAN (1078-1334): 2.54e-59: 218: 39.47		CD276_HUMAN (14-237): 3.81e-18: 86.3: 19.59
+	Dm
		1097967 ROR1_DROME (1054-1337): 4.69e-56: 209: 39.18		PTK7_DROME (84-286): 1.03e-17: 85.1: 21.33
+	Hs
		1070977 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		LRIG3_HUMAN (17-154): 1.15e-10: 64: 14.29
+	Dm
		1001983 Q0KIF1_DROME (438-555): 3.94e-27: 122: 26.45		PTK7_DROME (84-286): 1.03e-17: 85.1: 21.33