HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: TENS2 (Q63HR2)
Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
Gene: TNS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 1409
+	Hs
		441520 MET_HUMAN (1-1390): 0: 1283: 100.00		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		441536 MET_HUMAN (1-1390): 0: 1283: 100.00		TENS4_HUMAN (847-1409): 1.5e-44: 175: 32.50
+	Hs
		441420 MET_HUMAN (1-1390): 0: 1283: 100.00		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		441566 MET_HUMAN (1-1390): 0: 1283: 100.00		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34
+	Hs
		872663 EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		981941 RON_HUMAN (23-1390): 0: 934: 32.70		PCLO_HUMAN (529-1341): 4.77e-24: 112: 9.59
+	Hs
		674461 UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		1070974 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		782795 CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		665386 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		TPTE_HUMAN (107-424): 3.97e-104: 344: 25.15
+	Hs
		872609 EPHB1_HUMAN (597-1389): 2.34e-158: 505: 18.76		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Rn
		94036 INSR_RAT (1084-1335): 3.22e-52: 204: 40.98		F1LN91_RAT (31-1409): 0: 604: 33.49
+	Hs
		1070975 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		161637 PLXA3_HUMAN (381-1019): 8.58e-111: 388: 17.82		GAK_HUMAN (116-898): 4.56e-102: 357: 17.19
+	Hs
		665647 EPHB2_HUMAN (597-1389): 7.92e-156: 500: 18.91		ASPP1_HUMAN (749-1169): 6.23e-10: 66.1: 12.59
+	Hs
		1070981 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		TENS4_HUMAN (847-1409): 1.5e-44: 175: 32.50
+	Hs
		554307 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		337335 ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Rn
		88517 INSR_RAT (1084-1335): 3.22e-52: 204: 40.98		D3ZAP7_RAT (420-969): 1.35e-16: 88.2: 8.26
+	Hs
		1071015 ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34