HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.619

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 860
+	Hs
		275527 MET_HUMAN (1-1390): 0: 1283: 100.00		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		441415 MET_HUMAN (1-1390): 0: 1283: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (112-393): 2.09e-58: 210: 14.29
+	Hs
		441489 MET_HUMAN (1-1390): 0: 1283: 100.00		BTK_HUMAN (24-426): 1.81e-56: 208: 10.49
+	Hs
		441493 MET_HUMAN (1-1390): 0: 1283: 100.00		ITK_HUMAN (29-393): 7.98e-57: 208: 14.21
+	Hs
		426938 MET_HUMAN (1-1390): 0: 1283: 100.00		FES_HUMAN (1-394): 3.67e-54: 204: 18.75
+	Hs
		441471 MET_HUMAN (1-1390): 0: 1283: 100.00		BLK_HUMAN (108-394): 1.28e-54: 199: 13.44
+	Hs
		433529 MET_HUMAN (1-1390): 0: 1283: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411558 MET_HUMAN (1-1390): 0: 1283: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		441545 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC3_HUMAN (8-322): 9.13e-53: 196: 20.99
+	Hs
		441524 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC4_HUMAN (8-321): 2.53e-52: 195: 18.67
+	Hs
		441467 MET_HUMAN (1-1390): 0: 1283: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Hs
		441442 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC1_HUMAN (97-322): 5.53e-44: 170: 24.02
+	Hs
		441481 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC2_HUMAN (112-321): 2.18e-33: 138: 18.94
+	Hs
		441428 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG1_HUMAN (105-427): 7.42e-27: 120: 14.37
+	Hs
		441477 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB2_HUMAN (214-310): 1.18e-27: 113: 27.00
+	Hs
		208977 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72
+	Hs
		441439 MET_HUMAN (1-1390): 0: 1283: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58