HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: P55G (Q92569)
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)
Gene: PIK3R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.619

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 461
+	Hs
		441439 MET_HUMAN (1-1390): 0: 1283: 100.00		P85A_HUMAN (48-455): 9.1e-92: 295: 79.17
+	Hs
		129172 MET_HUMAN (1-1390): 0: 1283: 100.00		P85B_HUMAN (56-453): 2.19e-87: 283: 74.12
+	Hs
		146584 MET_HUMAN (1-1390): 0: 1283: 100.00		SOCS2_HUMAN (40-144): 7.17e-30: 117: 28.95
+	Hs
		441462 MET_HUMAN (1-1390): 0: 1283: 100.00		ABL2_HUMAN (324-459): 5.26e-21: 98.5: 25.36
+	Hs
		411558 MET_HUMAN (1-1390): 0: 1283: 100.00		LCK_HUMAN (309-458): 5.54e-21: 97.3: 25.95
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (310-458): 1.43e-19: 93.1: 26.75
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (317-459): 6.84e-19: 91.2: 23.72
+	Hs
		441415 MET_HUMAN (1-1390): 0: 1283: 100.00		SRC_HUMAN (323-459): 8.26e-19: 90.8: 24.14
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (323-459): 2.54e-18: 89.2: 26.21
+	Hs
		441471 MET_HUMAN (1-1390): 0: 1283: 100.00		BLK_HUMAN (285-458): 2.65e-18: 89.2: 23.50
+	Hs
		433529 MET_HUMAN (1-1390): 0: 1283: 100.00		LYN_HUMAN (298-458): 6.17e-18: 88.1: 24.85
+	Hs
		147476 MET_HUMAN (1-1390): 0: 1283: 100.00		SOCS6_HUMAN (47-165): 1.85e-17: 86.8: 31.06
+	Hs
		441580 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV3_HUMAN (44-159): 6.81e-16: 82.5: 30.17
+	Hs
		441481 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC2_HUMAN (39-162): 7.97e-14: 75.6: 30.65
+	Hs
		441472 MET_HUMAN (1-1390): 0: 1283: 100.00		VAV2_HUMAN (38-159): 4.46e-13: 73.7: 22.95
+	Hs
		441459 MET_HUMAN (1-1390): 0: 1283: 100.00		MATK_HUMAN (341-456): 1.11e-12: 71.8: 22.22
+	Hs
		441545 MET_HUMAN (1-1390): 0: 1283: 100.00		SHC3_HUMAN (43-164): 3.62e-12: 70.2: 31.15
+	Hs
		181774 MET_HUMAN (1-1390): 0: 1283: 100.00		SOCS1_HUMAN (46-169): 5.58e-13: 69.8: 23.20
+	Hs
		441423 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG2_HUMAN (337-452): 6.98e-12: 69.8: 33.33
+	Mm
		554964 MET_MOUSE (1-1381): 0: 1246: 89.57		FYN_MOUSE (326-459): 6.11e-20: 94.2: 26.06