HitPredict

Interactor 1: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1390 Hs			1 352
+	Hs
		441406 MET_HUMAN (1-1390): 0: 1283: 100.00		FGR_HUMAN (2-207): 1.19e-39: 148: 18.64
+	Hs
		433219 MET_HUMAN (1-1390): 0: 1283: 100.00		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		441569 MET_HUMAN (1-1390): 0: 1283: 100.00		SH22A_HUMAN (17-212): 4.9e-39: 144: 29.35
+	Hs
		441415 MET_HUMAN (1-1390): 0: 1283: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		411558 MET_HUMAN (1-1390): 0: 1283: 100.00		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		441403 MET_HUMAN (1-1390): 0: 1283: 100.00		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		441477 MET_HUMAN (1-1390): 0: 1283: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		441500 MET_HUMAN (1-1390): 0: 1283: 100.00		PTK6_HUMAN (30-149): 1.47e-32: 127: 28.46
+	Hs
		441422 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		441546 MET_HUMAN (1-1390): 0: 1283: 100.00		P55G_HUMAN (13-130): 1.15e-30: 122: 25.41
+	Mm
		554964 MET_MOUSE (1-1381): 0: 1246: 89.57		FYN_MOUSE (3-207): 5.32e-40: 149: 16.81
+	Hs
		441423 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG2_HUMAN (6-159): 1.15e-24: 107: 17.65
+	Hs
		441428 MET_HUMAN (1-1390): 0: 1283: 100.00		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		208977 MET_HUMAN (1-1390): 0: 1283: 100.00		NCK2_HUMAN (13-121): 6.71e-23: 100: 29.20
+	Mm
		101586 F8VQL0_MOUSE (1-1381): 0: 1244: 89.50		GRB2_MOUSE (14-150): 5.37e-35: 129: 24.66
+	Hs
		441466 MET_HUMAN (1-1390): 0: 1283: 100.00		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Hs
		441465 MET_HUMAN (1-1390): 0: 1283: 100.00		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20
+	Hs
		924497 RON_HUMAN (23-1390): 0: 934: 32.70		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		580981 RON_HUMAN (23-1390): 0: 934: 32.70		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		412036 EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81